miR25/93 mediates hypoxia-induced immunosuppression by repressing cGAS

The mechanisms by which hypoxic tumors evade immunological pressure and anti-tumor immunity remain elusive. Here, we report that two hypoxia-responsive microRNAs, miR25 and miR93, are important for establishing an immunosuppressive tumor microenvironment by down-regulating expression of the DNA-sens...

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Veröffentlicht in:Nat Cell Biol
Hauptverfasser: Wu, Min-Zu, Cheng, Wei-Chung, Chen, Su-Feng, Nieh, Shin, O’Connor, Carolyn, Liu, Chia-Lin, Tsai, Wen-Wei, Wu, Cheng-Jang, Martin, Lorena, Lin, Yaoh-Shiang, Wu, Kou-Juey, Lu, Li-Fan, Belmonte, Juan Carlos Izpisua
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5658024/
https://ncbi.nlm.nih.gov/pubmed/28920955
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb3615
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