Hypoxia, Epithelial-Mesenchymal Transition, and TET-Mediated Epigenetic Changes

Tumor hypoxia is a pathophysiologic outcome of disrupted microcirculation with inadequate supply of oxygen, leading to enhanced proliferation, epithelial-mesenchymal transition (EMT), metastasis, and chemo-resistance. Epigenetic changes induced by hypoxia are well documented, and they lead to tumor...

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Vydáno v:J Clin Med
Hlavní autoři: Kao, Shih-Han, Wu, Kou-Juey, Lee, Wen-Hwa
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2016
Témata:
Review
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4773780/
https://ncbi.nlm.nih.gov/pubmed/26861406
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/jcm5020024
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