TET1 regulates hypoxia-induced epithelial-mesenchymal transition by acting as a co-activator

BACKGROUND: Hypoxia induces the epithelial-mesenchymal transition, EMT, to promote cancer metastasis. In addition to transcriptional regulation mediated by hypoxia-inducible factors, HIFs, other epigenetic mechanisms of gene regulation, such as histone modifications and DNA methylation, are utilized...

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Publicado en:Genome Biol
Autores principales: Tsai, Ya-Ping, Chen, Hsiao-Fan, Chen, Sung-Yuan, Cheng, Wei-Chung, Wang, Hsei-Wei, Shen, Zih-Jie, Song, Chunxiao, Teng, Shu-Chun, He, Chuan, Wu, Kou-Juey
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4253621/
https://ncbi.nlm.nih.gov/pubmed/25517638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-014-0513-0
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