Colibactin assembly line enzymes use S-adenosylmethionine to build a cyclopropane ring

Despite containing an α-amino acid, the versatile cofactor S-adenosylmethionine (SAM) is not a known building block for non-ribosomal peptide synthetase (NRPS) assembly lines. Here we report an unusual NRPS module from colibactin biosynthesis that uses SAM for amide bond formation and subsequent cyc...

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Bibliographic Details
Published in:Nat Chem Biol
Main Authors: Zha, Li, Jiang, Yindi, Henke, Matthew T., Wilson, Matthew R., Wang, Jennifer X., Kelleher, Neil L., Balskus, Emily P.
Format: Artigo
Language:Inglês
Published: 2017
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5657534/
https://ncbi.nlm.nih.gov/pubmed/28805802
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.2448
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