Multivalency Increases the Binding Strength of RGD Peptidomimetic‐Paclitaxel Conjugates to Integrin α(V)β(3)

This work reports the synthesis of three multimeric RGD peptidomimetic‐paclitaxel conjugates featuring a number of α(V)β(3) integrin ligands ranging from 2 to 4. These constructs were assembled by conjugation of the integrin α(V)β(3) ligand cyclo[DKP‐RGD]‐CH(2)NH(2) with paclitaxel via a 2′‐carbamat...

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Bibliografske podrobnosti
izdano v:Chemistry
Main Authors: Raposo Moreira Dias, André, Pina, Arianna, Dal Corso, Alberto, Arosio, Daniela, Belvisi, Laura, Pignataro, Luca, Caruso, Michele, Gennari, Cesare
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2017
Teme:
Communications
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5656903/
https://ncbi.nlm.nih.gov/pubmed/28816404
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chem.201703093
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