Spironolactone is an antagonist of NRG1‐ERBB4 signaling and schizophrenia‐relevant endophenotypes in mice

Enhanced NRG1‐ERBB4 signaling is a risk pathway in schizophrenia, and corresponding mouse models display several endophenotypes of the disease. Nonetheless, pathway‐directed treatment strategies with clinically applicable compounds have not been identified. Here, we applied a cell‐based assay using...

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Vydáno v:EMBO Mol Med
Hlavní autoři: Wehr, Michael C, Hinrichs, Wilko, Brzózka, Magdalena M, Unterbarnscheidt, Tilmann, Herholt, Alexander, Wintgens, Jan P, Papiol, Sergi, Soto‐Bernardini, Maria Clara, Kravchenko, Mykola, Zhang, Mingyue, Nave, Klaus‐Armin, Wichert, Sven P, Falkai, Peter, Zhang, Weiqi, Schwab, Markus H, Rossner, Moritz J
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2017
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5653977/
https://ncbi.nlm.nih.gov/pubmed/28743784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.201707691
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