Spironolactone is an antagonist of NRG1‐ERBB4 signaling and schizophrenia‐relevant endophenotypes in mice

Enhanced NRG1‐ERBB4 signaling is a risk pathway in schizophrenia, and corresponding mouse models display several endophenotypes of the disease. Nonetheless, pathway‐directed treatment strategies with clinically applicable compounds have not been identified. Here, we applied a cell‐based assay using...

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Detalhes bibliográficos
Publicado no:EMBO Mol Med
Main Authors: Wehr, Michael C, Hinrichs, Wilko, Brzózka, Magdalena M, Unterbarnscheidt, Tilmann, Herholt, Alexander, Wintgens, Jan P, Papiol, Sergi, Soto‐Bernardini, Maria Clara, Kravchenko, Mykola, Zhang, Mingyue, Nave, Klaus‐Armin, Wichert, Sven P, Falkai, Peter, Zhang, Weiqi, Schwab, Markus H, Rossner, Moritz J
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5653977/
https://ncbi.nlm.nih.gov/pubmed/28743784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.201707691
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