BACE1 Processing of NRG1 Type III Produces a Myelin-Inducing Signal but Is Not Essential for the Stimulation of Myelination

Myelin sheath thickness is precisely adjusted to axon caliber, and in the peripheral nervous system, neuregulin 1 (NRG1) type III is a key regulator of this process. It has been proposed that the protease BACE1 activates NRG1 dependent myelination. Here, we characterize the predicted product of BACE...

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Detalhes bibliográficos
Main Authors: Velanac, Viktorija, Unterbarnscheidt, Tilmann, Hinrichs, Wilko, Gummert, Maike N, Fischer, Tobias M, Rossner, Moritz J, Trimarco, Amelia, Brivio, Veronica, Taveggia, Carla, Willem, Michael, Haass, Christian, Möbius, Wiebke, Nave, Klaus-Armin, Schwab, Markus H
Formato: Artigo
Idioma:Inglês
Publicado em: Wiley Subscription Services, Inc., A Wiley Company 2012
Assuntos:
Original Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3267053/
https://ncbi.nlm.nih.gov/pubmed/22052506
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/glia.21255
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