Mice Lacking the Circadian Modulators SHARP1 and SHARP2 Display Altered Sleep and Mixed State Endophenotypes of Psychiatric Disorders

Increasing evidence suggests that clock genes may be implicated in a spectrum of psychiatric diseases, including sleep and mood related disorders as well as schizophrenia. The bHLH transcription factors SHARP1/DEC2/BHLHE41 and SHARP2/DEC1/BHLHE40 are modulators of the circadian system and SHARP1/DEC...

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Autors principals: Baier, Paul C., Brzózka, Magdalena M., Shahmoradi, Ali, Reinecke, Lisa, Kroos, Christina, Wichert, Sven P., Oster, Henrik, Wehr, Michael C., Taneja, Reshma, Hirrlinger, Johannes, Rossner, Moritz J.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2014
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Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4207740/
https://ncbi.nlm.nih.gov/pubmed/25340473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0110310
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