Desulfation of Heparan Sulfate by Sulf1 and Sulf2 Is Required for Corticospinal Tract Formation

Heparan sulfate (HS) has been implicated in a wide range of cell signaling. Here we report a novel mechanism in which extracellular removal of 6-O-sulfate groups from HS by the endosulfatases, Sulf1 and Sulf2, is essential for axon guidance during development. In Sulf1/2 double knockout (DKO) mice,...

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Publicado no:Sci Rep
Main Authors: Okada, Takuya, Keino-Masu, Kazuko, Nagamine, Satoshi, Kametani, Fuyuki, Ohto, Tatsuyuki, Hasegawa, Masato, van Kuppevelt, Toin H., Kunita, Satoshi, Takahashi, Satoru, Masu, Masayuki
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5653861/
https://ncbi.nlm.nih.gov/pubmed/29062064
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-14185-3
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