Organ-specific Sulfation Patterns of Heparan Sulfate Generated by Extracellular Sulfatases Sulf1 and Sulf2 in Mice

Heparan sulfate endosulfatases Sulf1 and Sulf2 hydrolyze 6-O-sulfate in heparan sulfate, thereby regulating cellular signaling. Previous studies have revealed that Sulfs act predominantly on UA2S-GlcNS6S disaccharides and weakly on UA-GlcNS6S disaccharides. However, the specificity of Sulfs and thei...

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Bibliografiske detaljer
Main Authors: Nagamine, Satoshi, Tamba, Michiko, Ishimine, Hisako, Araki, Kota, Shiomi, Kensuke, Okada, Takuya, Ohto, Tatsuyuki, Kunita, Satoshi, Takahashi, Satoru, Wismans, Ronnie G. P., van Kuppevelt, Toin H., Masu, Masayuki, Keino-Masu, Kazuko
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2012
Fag:
Glycobiology and Extracellular Matrices
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3308746/
https://ncbi.nlm.nih.gov/pubmed/22298771
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.290262
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