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Overcoming resistance to BRAF inhibitors
The discovery of activating mutations in the serine/threonine (S/T) kinase BRAF followed by a wave of follow-up research manifested that the MAPK-pathway plays a critical role in melanoma initiation and progression. BRAF and MEK inhibitors produce an unparalleled response rate in melanoma, but it is...
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| Publicado no: | Ann Transl Med |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
AME Publishing Company
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5653517/ https://ncbi.nlm.nih.gov/pubmed/29114545 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.21037/atm.2017.06.09 |
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