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Overcoming resistance to BRAF inhibition in BRAF-mutated metastatic melanoma

Almost 50% of metastatic melanoma patients harbor a BRAF(V600) mutation andthe introduction of BRAF inhibitors has improved their treatment options. BRAF inhibitors vemurafenib and dabrafenib achieved improved overall survival over chemotherapy and have been approved for the treatment of BRAF-mutate...

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Detalles Bibliográficos
Publicado en:Oncotarget
Main Authors: Spagnolo, Francesco, Ghiorzo, Paola, Queirolo, Paola
Formato: Artigo
Idioma:Inglês
Publicado: Impact Journals LLC 2014
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4279367/
https://ncbi.nlm.nih.gov/pubmed/25344914
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