Molecular mechanisms of programmed cell death-1 dependent T cell suppression: relevance for immunotherapy

Programmed cell death-1 (PD1) has become a significant target for cancer immunotherapy. PD1 and its receptor programmed cell death 1 ligand 1 (PDL1) are key regulatory physiological immune checkpoints that maintain self-tolerance in the organism by regulating the degree of activation of T and B cell...

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Detalhes bibliográficos
Publicado no:Ann Transl Med
Main Authors: Zuazo, Miren, Gato-Cañas, Maria, Llorente, Noelia, Ibañez-Vea, María, Arasanz, Hugo, Kochan, Grazyna, Escors, David
Formato: Artigo
Idioma:Inglês
Publicado em: AME Publishing Company 2017
Assuntos:
Review Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5653513/
https://ncbi.nlm.nih.gov/pubmed/29114543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.21037/atm.2017.06.11
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