Molecular mechanisms of programmed cell death-1 dependent T cell suppression: relevance for immunotherapy

Programmed cell death-1 (PD1) has become a significant target for cancer immunotherapy. PD1 and its receptor programmed cell death 1 ligand 1 (PDL1) are key regulatory physiological immune checkpoints that maintain self-tolerance in the organism by regulating the degree of activation of T and B cell...

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Vydáno v:Ann Transl Med
Hlavní autoři: Zuazo, Miren, Gato-Cañas, Maria, Llorente, Noelia, Ibañez-Vea, María, Arasanz, Hugo, Kochan, Grazyna, Escors, David
Médium: Artigo
Jazyk:Inglês
Vydáno: AME Publishing Company 2017
Témata:
Review Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5653513/
https://ncbi.nlm.nih.gov/pubmed/29114543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.21037/atm.2017.06.11
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