Modulation of the Fanconi anemia pathway via chemically induced changes in chromatin structure

Fanconi anemia (FA) is a rare disease characterized by congenital defects, bone marrow failure, and atypically early-onset cancers. The FA proteins function cooperatively to repair DNA interstrand crosslinks. A major step in the activation of the pathway is the monoubiquitination of the FANCD2 and F...

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Udgivet i:Oncotarget
Main Authors: Vierra, David A., Garzon, Jada L., Rego, Meghan A., Adroved, Morganne M., Mauro, Maurizio, Howlett, Niall G.
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2017
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5652718/
https://ncbi.nlm.nih.gov/pubmed/29100324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.19470
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