MDM2 Antagonists Counteract Drug-Induced DNA Damage

Antagonists of MDM2-p53 interaction are emerging anti-cancer drugs utilized in clinical trials for malignancies that rarely mutate p53, including melanoma. We discovered that MDM2-p53 antagonists protect DNA from drug-induced damage in melanoma cells and patient-derived xenografts. Among the tested...

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發表在:EBioMedicine
Main Authors: Vilgelm, Anna E., Cobb, Priscilla, Malikayil, Kiran, Flaherty, David, Andrew Johnson, C., Raman, Dayanidhi, Saleh, Nabil, Higgins, Brian, Vara, Brandon A., Johnston, Jeffrey N., Johnson, Douglas B., Kelley, Mark C., Chen, Sheau-Chiann, Ayers, Gregory D., Richmond, Ann
格式: Artigo
語言:Inglês
出版: Elsevier 2017
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Research Paper
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5652019/
https://ncbi.nlm.nih.gov/pubmed/29030058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2017.09.016
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