MDM2 Antagonists Counteract Drug-Induced DNA Damage

Antagonists of MDM2-p53 interaction are emerging anti-cancer drugs utilized in clinical trials for malignancies that rarely mutate p53, including melanoma. We discovered that MDM2-p53 antagonists protect DNA from drug-induced damage in melanoma cells and patient-derived xenografts. Among the tested...

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Detalhes bibliográficos
Publicado no:EBioMedicine
Main Authors: Vilgelm, Anna E., Cobb, Priscilla, Malikayil, Kiran, Flaherty, David, Andrew Johnson, C., Raman, Dayanidhi, Saleh, Nabil, Higgins, Brian, Vara, Brandon A., Johnston, Jeffrey N., Johnson, Douglas B., Kelley, Mark C., Chen, Sheau-Chiann, Ayers, Gregory D., Richmond, Ann
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5652019/
https://ncbi.nlm.nih.gov/pubmed/29030058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2017.09.016
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