MDM2 Antagonists Counteract Drug-Induced DNA Damage

Antagonists of MDM2-p53 interaction are emerging anti-cancer drugs utilized in clinical trials for malignancies that rarely mutate p53, including melanoma. We discovered that MDM2-p53 antagonists protect DNA from drug-induced damage in melanoma cells and patient-derived xenografts. Among the tested...

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Dades bibliogràfiques
Publicat a:EBioMedicine
Autors principals: Vilgelm, Anna E., Cobb, Priscilla, Malikayil, Kiran, Flaherty, David, Andrew Johnson, C., Raman, Dayanidhi, Saleh, Nabil, Higgins, Brian, Vara, Brandon A., Johnston, Jeffrey N., Johnson, Douglas B., Kelley, Mark C., Chen, Sheau-Chiann, Ayers, Gregory D., Richmond, Ann
Format: Artigo
Idioma:Inglês
Publicat: Elsevier 2017
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5652019/
https://ncbi.nlm.nih.gov/pubmed/29030058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2017.09.016
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