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Connecting the Dots: Therapy-Induced Senescence and a Tumor-Suppressive Immune Microenvironment
BACKGROUND: Tumor cell senescence is a common outcome of anticancer therapy. Here we investigated how therapy-induced senescence (TIS) affects tumor-infiltrating leukocytes (TILs) and the efficacy of immunotherapy in melanoma. METHODS: Tumor senescence was induced by AURKA or CDK4/6 inhibitors (AURK...
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| Publicat a: | J Natl Cancer Inst |
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| Autors principals: | , , , , , , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Oxford University Press
2015
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4849355/ https://ncbi.nlm.nih.gov/pubmed/26719346 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jnci/djv406 |
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