Connecting the Dots: Therapy-Induced Senescence and a Tumor-Suppressive Immune Microenvironment

BACKGROUND: Tumor cell senescence is a common outcome of anticancer therapy. Here we investigated how therapy-induced senescence (TIS) affects tumor-infiltrating leukocytes (TILs) and the efficacy of immunotherapy in melanoma. METHODS: Tumor senescence was induced by AURKA or CDK4/6 inhibitors (AURK...

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Pubblicato in:J Natl Cancer Inst
Autori principali: Vilgelm, Anna E., Johnson, C. Andrew, Prasad, Nripesh, Yang, Jinming, Chen, Sheau-Chiann, Ayers, Gregory D., Pawlikowski, Jeff S., Raman, Dayanidhi, Sosman, Jeffrey A., Kelley, Mark, Ecsedy, Jeffrey A., Shyr, Yu, Levy, Shawn E., Richmond, Ann
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4849355/
https://ncbi.nlm.nih.gov/pubmed/26719346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jnci/djv406
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