Targeting aurora kinases limits tumour growth through DNA damage-mediated senescence and blockade of NF-κB impairs this drug-induced senescence

Oncogene-induced senescence can provide a protective mechanism against tumour progression. However, production of cytokines and growth factors by senescent cells may contribute to tumour development. Thus, it is unclear whether induction of senescence represents a viable therapeutic approach. Here,...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Liu, Yan, Hawkins, Oriana E, Su, Yingjun, Vilgelm, Anna E, Sobolik, Tammy, Thu, Yee-Mon, Kantrow, Sara, Splittgerber, Ryan C, Short, Sarah, Amiri, Katayoun I, Ecsedy, Jeffery A, Sosman, Jeffery A, Kelley, Mark C, Richmond, Ann
Formato: Artigo
Idioma:Inglês
Publicado em: WILEY-VCH Verlag 2013
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3569660/
https://ncbi.nlm.nih.gov/pubmed/23180582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/emmm.201201378
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados