Targeting aurora kinases limits tumour growth through DNA damage-mediated senescence and blockade of NF-κB impairs this drug-induced senescence

Oncogene-induced senescence can provide a protective mechanism against tumour progression. However, production of cytokines and growth factors by senescent cells may contribute to tumour development. Thus, it is unclear whether induction of senescence represents a viable therapeutic approach. Here,...

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Main Authors: Liu, Yan, Hawkins, Oriana E, Su, Yingjun, Vilgelm, Anna E, Sobolik, Tammy, Thu, Yee-Mon, Kantrow, Sara, Splittgerber, Ryan C, Short, Sarah, Amiri, Katayoun I, Ecsedy, Jeffery A, Sosman, Jeffery A, Kelley, Mark C, Richmond, Ann
פורמט: Artigo
שפה:Inglês
יצא לאור: WILEY-VCH Verlag 2013
נושאים:
Research Articles
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3569660/
https://ncbi.nlm.nih.gov/pubmed/23180582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/emmm.201201378
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