Mdm2 and Aurora A inhibitors synergize to block melanoma growth by driving apoptosis and immune clearance of tumor cells

Therapeutics that induce cancer cell senescence can block cell proliferation and promote immune rejection. However, the risk of tumor relapse due to senescence escape may remain high due to the long lifespan of senescent cells that are not cleared. Here we show how combining a senescence-inducing in...

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Detalhes bibliográficos
Publicado no:Cancer Res
Main Authors: Vilgelm, Anna E., Pawlikowski, Jeff S., Liu, Yan, Hawkins, Oriana E., Davis, Tyler A., Smith, Jessica, Weller, Kevin P., Horton, Linda W., McClain, Colt M., Ayers, Gregory D., Turner, David C., Essaka, David C., Stewart, Clinton F., Sosman, Jeffrey A., Kelley, Mark C., Ecsedy, Jeffrey A., Johnston, Jeffrey N., Richmond, Ann
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4286469/
https://ncbi.nlm.nih.gov/pubmed/25398437
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-14-2405
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