Passage-dependent cancerous transformation of human mesenchymal stem cells under carcinogenic hypoxia

Bone marrow-derived human mesenchymal stem cells (hMSCs) either promote or inhibit cancer progression, depending on factors that heretofore have been undefined. Here we have utilized extreme hypoxia (0.5% O(2)) and concurrent treatment with metal carcinogen (nickel) to evaluate the passage-dependent...

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Autores principales: Crowder, Spencer W., Horton, Linda W., Lee, Sue Hyun, McClain, Colt M., Hawkins, Oriana E., Palmer, Amanda M., Bae, Hojae, Richmond, Ann, Sung, Hak-Joon
Formato: Artigo
Lenguaje:Inglês
Publicado: Federation of American Societies for Experimental Biology 2013
Materias:
Research Communications
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3688746/
https://ncbi.nlm.nih.gov/pubmed/23568779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.13-228288
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