MDM2 Antagonists Overcome Intrinsic Resistance to CDK4/6 Inhibition by Inducing p21

Intrinsic resistance of unknown mechanism impedes the clinical utility of inhibitors of cyclin-dependent kinases 4 and 6 (CDK4/6i) in malignancies other than breast cancer. Here we used melanoma patient-derived xenografts (PDXs) to study the mechanisms for CDK4/6i resistance in pre-clinical settings...

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Detalhes bibliográficos
Publicado no:Sci Transl Med
Main Authors: Vilgelm, Anna E., Saleh, Nabil, Shattuck-Brandt, Rebecca, Riemenschneider, Kelsie, Slesur, Lauren, Chen, Sheau-Chiann, Johnson, C. Andrew, Yang, Jinming, Blevins, Ashlyn, Yan, Chi, Johnson, Douglas B., Al-Rohil, Rami N., Halilovic, Ensar, Kauffmann, Rondi M., Kelley, Mark, Ayers, Gregory D., Richmond, Ann
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7584132/
https://ncbi.nlm.nih.gov/pubmed/31413145
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aav7171
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