The Indirubin Derivative 6-Bromoindirubin-3′-Oxime Activates Proteostatic Modules, Reprograms Cellular Bioenergetic Pathways, and Exerts Antiaging Effects

Aims: Organismal aging can be delayed by mutations that either activate stress responses or reduce the nutrient-sensing pathway signaling; thus, by using Drosophila melanogaster as an in vivo experimental screening platform, we searched for compounds that modulate these pathways. Results: We noted t...

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Udgivet i:Antioxid Redox Signal
Main Authors: Tsakiri, Eleni N., Gaboriaud-Kolar, Nicolas, Iliaki, Kalliopi K., Tchoumtchoua, Job, Papanagnou, Eleni-Dimitra, Chatzigeorgiou, Sofia, Tallas, Konstantinos D., Mikros, Emmanuel, Halabalaki, Maria, Skaltsounis, Alexios-Leandros, Trougakos, Ioannis P.
Format: Artigo
Sprog:Inglês
Udgivet: Mary Ann Liebert, Inc. 2017
Fag:
Original Research Communications
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5651956/
https://ncbi.nlm.nih.gov/pubmed/28253732
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/ars.2016.6910
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