Molecular mechanisms and structural features of cardiomyopathy-causing troponin T mutants in the tropomyosin overlap region

Point mutations in genes encoding sarcomeric proteins are the leading cause of inherited primary cardiomyopathies. Among them are mutations in the TNNT2 gene that encodes cardiac troponin T (TnT). These mutations are clustered in the tropomyosin (Tm) binding region of TnT, TNT1 (residues 80–180). To...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Gangadharan, Binnu, Sunitha, Margaret S., Mukherjee, Souhrid, Chowdhury, Ritu Roy, Haque, Farah, Sekar, Narendrakumar, Sowdhamini, Ramanathan, Spudich, James A., Mercer, John A.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2017
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5651771/
https://ncbi.nlm.nih.gov/pubmed/28973951
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1710354114
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