Mechanistic Heterogeneity in Contractile Properties of α-Tropomyosin (TPM1) Mutants Associated with Inherited Cardiomyopathies

The most frequent known causes of primary cardiomyopathies are mutations in the genes encoding sarcomeric proteins. Among those are 30 single-residue mutations in TPM1, the gene encoding α-tropomyosin. We examined seven mutant tropomyosins, E62Q, D84N, I172T, L185R, S215L, D230N, and M281T, that wer...

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Dettagli Bibliografici
Pubblicato in:J Biol Chem
Autori principali: Gupte, Tejas M., Haque, Farah, Gangadharan, Binnu, Sunitha, Margaret S., Mukherjee, Souhrid, Anandhan, Swetha, Rani, Deepa Selvi, Mukundan, Namita, Jambekar, Amruta, Thangaraj, Kumarasamy, Sowdhamini, Ramanathan, Sommese, Ruth F., Nag, Suman, Spudich, James A., Mercer, John A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2015
Soggetti:
Molecular Bases of Disease
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4358124/
https://ncbi.nlm.nih.gov/pubmed/25548289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.596676
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