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Integrative Structural Modelling of the Cardiac Thin Filament: Energetics at the Interface and Conservation Patterns Reveal a Spotlight on Period 2 of Tropomyosin

Cardiomyopathies are a major health problem, with inherited cardiomyopathies, many of which are caused by mutations in genes encoding sarcomeric proteins, constituting an ever-increasing fraction of cases. To begin to study the mechanisms by which these mutations cause disease, we have employed an i...

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Détails bibliographiques
Auteurs principaux: Margaret Sunitha, S, Mercer, John A., Spudich, James A., Sowdhamini, Ramanathan
Format: Artigo
Langue:Inglês
Publié: Libertas Academica 2012
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3468436/
https://ncbi.nlm.nih.gov/pubmed/23071391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4137/BBI.S9798
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