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Molecular mechanisms and structural features of cardiomyopathy-causing troponin T mutants in the tropomyosin overlap region

Point mutations in genes encoding sarcomeric proteins are the leading cause of inherited primary cardiomyopathies. Among them are mutations in the TNNT2 gene that encodes cardiac troponin T (TnT). These mutations are clustered in the tropomyosin (Tm) binding region of TnT, TNT1 (residues 80–180). To...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Gangadharan, Binnu, Sunitha, Margaret S., Mukherjee, Souhrid, Chowdhury, Ritu Roy, Haque, Farah, Sekar, Narendrakumar, Sowdhamini, Ramanathan, Spudich, James A., Mercer, John A.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5651771/
https://ncbi.nlm.nih.gov/pubmed/28973951
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1710354114
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