Molecular mechanisms and structural features of cardiomyopathy-causing troponin T mutants in the tropomyosin overlap region

Point mutations in genes encoding sarcomeric proteins are the leading cause of inherited primary cardiomyopathies. Among them are mutations in the TNNT2 gene that encodes cardiac troponin T (TnT). These mutations are clustered in the tropomyosin (Tm) binding region of TnT, TNT1 (residues 80–180). To...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Gangadharan, Binnu, Sunitha, Margaret S., Mukherjee, Souhrid, Chowdhury, Ritu Roy, Haque, Farah, Sekar, Narendrakumar, Sowdhamini, Ramanathan, Spudich, James A., Mercer, John A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2017
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5651771/
https://ncbi.nlm.nih.gov/pubmed/28973951
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1710354114
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