The interaction of tropomodulin with tropomyosin stabilizes thin filaments in cardiac myocytes

Actin (thin) filament length regulation and stability are essential for striated muscle function. To determine the role of the actin filament pointed end capping protein, tropomodulin1 (Tmod1), with tropomyosin, we generated monoclonal antibodies (mAb17 and mAb8) against Tmod1 that specifically disr...

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Hauptverfasser: Mudry, Ryan E., Perry, Cynthia N., Richards, Meredith, Fowler, Velia M., Gregorio, Carol C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Rockefeller University Press 2003
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2172850/
https://ncbi.nlm.nih.gov/pubmed/12975349
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200305031
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