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Tropomodulin 1 directly controls thin filament length in both wild-type and tropomodulin 4-deficient skeletal muscle

The sarcomeric tropomodulin (Tmod) isoforms Tmod1 and Tmod4 cap thin filament pointed ends and functionally interact with the leiomodin (Lmod) isoforms Lmod2 and Lmod3 to control myofibril organization, thin filament lengths, and actomyosin crossbridge formation in skeletal muscle fibers. Here, we s...

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Bibliografiske detaljer
Udgivet i:Development
Main Authors: Gokhin, David S., Ochala, Julien, Domenighetti, Andrea A., Fowler, Velia M.
Format: Artigo
Sprog:Inglês
Udgivet: The Company of Biologists 2015
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4689220/
https://ncbi.nlm.nih.gov/pubmed/26586224
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.129171
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