Mechanistic Heterogeneity in Contractile Properties of α-Tropomyosin (TPM1) Mutants Associated with Inherited Cardiomyopathies

The most frequent known causes of primary cardiomyopathies are mutations in the genes encoding sarcomeric proteins. Among those are 30 single-residue mutations in TPM1, the gene encoding α-tropomyosin. We examined seven mutant tropomyosins, E62Q, D84N, I172T, L185R, S215L, D230N, and M281T, that wer...

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Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:J Biol Chem
Κύριοι συγγραφείς: Gupte, Tejas M., Haque, Farah, Gangadharan, Binnu, Sunitha, Margaret S., Mukherjee, Souhrid, Anandhan, Swetha, Rani, Deepa Selvi, Mukundan, Namita, Jambekar, Amruta, Thangaraj, Kumarasamy, Sowdhamini, Ramanathan, Sommese, Ruth F., Nag, Suman, Spudich, James A., Mercer, John A.
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: American Society for Biochemistry and Molecular Biology 2015
Θέματα:
Molecular Bases of Disease
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4358124/
https://ncbi.nlm.nih.gov/pubmed/25548289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.596676
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