High-Pressure-Driven Reversible Dissociation of α-Synuclein Fibrils Reveals Structural Hierarchy

The analysis of the α-synuclein (aS) aggregation process, which is involved in Parkinson’s disease etiopathogenesis, and of the structural feature of the resulting amyloid fibrils may shed light on the relationship between the structure of aS aggregates and their toxicity. This may be considered a p...

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Detalhes bibliográficos
Publicado no:Biophys J
Main Authors: Piccirilli, Federica, Plotegher, Nicoletta, Ortore, Maria Grazia, Tessari, Isabella, Brucale, Marco, Spinozzi, Francesco, Beltramini, Mariano, Mariani, Paolo, Militello, Valeria, Lupi, Stefano, Perucchi, Andrea, Bubacco, Luigi
Formato: Artigo
Idioma:Inglês
Publicado em: The Biophysical Society 2017
Assuntos:
Proteins
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5647593/
https://ncbi.nlm.nih.gov/pubmed/29045863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2017.08.042
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