High-Pressure-Driven Reversible Dissociation of α-Synuclein Fibrils Reveals Structural Hierarchy

The analysis of the α-synuclein (aS) aggregation process, which is involved in Parkinson’s disease etiopathogenesis, and of the structural feature of the resulting amyloid fibrils may shed light on the relationship between the structure of aS aggregates and their toxicity. This may be considered a p...

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Bibliographic Details
Published in:Biophys J
Main Authors: Piccirilli, Federica, Plotegher, Nicoletta, Ortore, Maria Grazia, Tessari, Isabella, Brucale, Marco, Spinozzi, Francesco, Beltramini, Mariano, Mariani, Paolo, Militello, Valeria, Lupi, Stefano, Perucchi, Andrea, Bubacco, Luigi
Format: Artigo
Language:Inglês
Published: The Biophysical Society 2017
Subjects:
Proteins
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5647593/
https://ncbi.nlm.nih.gov/pubmed/29045863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2017.08.042
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