Cardiac Reprogramming Factor Gata4 Reduces Post-Infarct Cardiac Fibrosis through Direct Repression of the Pro-Fibrotic Mediator Snail

OBJECTIVE: The administration of a variety of reprogramming factor cocktails has now been shown to reprogram cardiac fibroblasts into induced cardiomyocyte-like cells (iCMs). Reductions in ventricular fibrosis observed after reprogramming factor administration, however, seem to far exceed the extent...

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Publicado en:J Thorac Cardiovasc Surg
Autores principales: Mathison, Megumi, Singh, Vivek P., Sanagasetti, Deepthi, Yang, Lina, Pinnamaneni, Jaya Pratap, Yang, Jianchang, Rosengart, Todd K.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2017
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5647235/
https://ncbi.nlm.nih.gov/pubmed/28711329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jtcvs.2017.06.035
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