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Competitive Antagonism of Anesthetic Action at the γ-Aminobutyric Acid Type A Receptor by a Novel Etomidate Analogue with Low Intrinsic Efficacy
BACKGROUND: The authors characterized the γ-aminobutyric acid type A (GABA(A)) receptor pharmacology of the novel etomidate analogue naphthalene-etomidate, a potential lead compound for the development of anesthetic-selective competitive antagonists. METHODS: The positive modulatory potencies and ef...
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| Udgivet i: | Anesthesiology |
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| Main Authors: | , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2017
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5645246/ https://ncbi.nlm.nih.gov/pubmed/28857763 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/ALN.0000000000001840 |
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