Competitive Antagonism of Anesthetic Action at the γ-Aminobutyric Acid Type A Receptor by a Novel Etomidate Analogue with Low Intrinsic Efficacy

BACKGROUND: The authors characterized the γ-aminobutyric acid type A (GABA(A)) receptor pharmacology of the novel etomidate analogue naphthalene-etomidate, a potential lead compound for the development of anesthetic-selective competitive antagonists. METHODS: The positive modulatory potencies and ef...

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Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Anesthesiology
Päätekijät: Ma, Celena, Pejo, Ervin, McGrath, Megan, Jayakar, Selwyn S., Zhou, Xiaojuan, Miller, Keith W, Cohen, Jonathan B., Raines, Douglas E.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2017
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5645246/
https://ncbi.nlm.nih.gov/pubmed/28857763
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/ALN.0000000000001840
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