A systematic investigation of the maximum tolerated dose of cytotoxic chemotherapy with and without supportive care in mice

BACKGROUND: Cytotoxic chemotherapeutics form the cornerstone of systemic treatment of many cancers. Patients are dosed at maximum tolerated dose (MTD), which is carefully determined in phase I studies. In contrast, in murine studies, dosages are often based on customary practice or small pilot studi...

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Publicado en:BMC Cancer
Autores principales: Aston, Wayne J., Hope, Danika E., Nowak, Anna K., Robinson, Bruce W., Lake, Richard A., Lesterhuis, W. Joost
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2017
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5644108/
https://ncbi.nlm.nih.gov/pubmed/29037232
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-017-3677-7
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