Comprehensive Testing of Chemotherapy and Immune Checkpoint Blockade in Preclinical Cancer Models Identifies Additive Combinations

Antibodies that target immune checkpoints such as cytotoxic T lymphocyte antigen 4 (CTLA‐4) and the programmed cell death protein 1/ligand 1 (PD-1/PD-L1) are now a treatment option for multiple cancer types. However, as a monotherapy, objective responses only occur in a minority of patients. Chemoth...

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Detalhes bibliográficos
Main Authors: Nicola Principe, Wayne J. Aston, Danika E. Hope, Caitlin M. Tilsed, Scott A. Fisher, Louis Boon, Ian M. Dick, Wee Loong Chin, Alison M. McDonnell, Anna K. Nowak, Richard A. Lake, Jonathan Chee, Willem Joost Lesterhuis
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2022-05-01
Colecção:Frontiers in Immunology
Assuntos:
chemo-immunotherapy combinations
immune checkpoint blockade (ICB) therapy
T cells
proinflammatory cytokine
TNFa = tumor necrosis factor–a
IL-1b
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fimmu.2022.872295/full
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