(Pro)renin Receptor Activation Increases Profibrotic Markers and Fibroblast-like Phenotype Through MAPK-dependent ROS Formation In Mouse Renal Collecting Duct Cells

Recent studies suggested that activation of the PRR upregulates profibrotic markers through reactive oxygen species (ROS) formation; however, the exact mechanisms have not been investigated in CD cells. We hypothesized that activation of the PRR increases the expression of profibrotic markers throug...

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Udgivet i:Clin Exp Pharmacol Physiol
Main Authors: Gonzalez, Alexis A., Zamora, Leonardo, Reyes-Martinez, Cristian, Salinas-Parra, Nicolas, Roldan, Nicole, Cuevas, Catherina A., Figueroa, Stefanny, Gonzalez-Vergara, Alex, Prieto, Minolfa C.
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5643228/
https://ncbi.nlm.nih.gov/pubmed/28696542
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/1440-1681.12813
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