α-Ketoglutarate Upregulates Collecting Duct (Pro)renin Receptor Expression, Tubular Angiotensin II Formation, and Na(+) Reabsorption During High Glucose Conditions

Diabetes mellitus (DM) causes high glucose (HG) levels in the plasma and urine. The (pro)renin receptor (PRR) is a key regulator of renal Na(+) handling. PRR is expressed in intercalated (IC) cells of the collecting duct (CD) and binds renin to promote angiotensin (Ang) II formation, thereby contrib...

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Bibliografiske detaljer
Udgivet i:Front Cardiovasc Med
Main Authors: Guerrero, Aarón, Visniauskas, Bruna, Cárdenas, Pilar, Figueroa, Stefanny M., Vivanco, Jorge, Salinas-Parra, Nicolas, Araos, Patricio, Nguyen, Quynh My, Kassan, Modar, Amador, Cristián A., Prieto, Minolfa C., Gonzalez, Alexis A.
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2021
Fag:
Cardiovascular Medicine
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8220822/
https://ncbi.nlm.nih.gov/pubmed/34179130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcvm.2021.644797
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