(Pro)renin Receptor-Dependent Induction of Profibrotic Factors Is Mediated by COX-2/EP4/NOX-4/Smad Pathway in Collecting Duct Cells

The binding of prorenin to the (pro)renin receptor (PRR) triggers the activation of MAPK/ERK1/2 pathway, induction of cyclooxygenase-2 (COX-2), NOX-4-dependent production of reactive oxygen species (ROS), and the induction of transforming growth factor β (TGF-β) and profibrotic factors connecting ti...

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Bibliografiske detaljer
Udgivet i:Front Pharmacol
Main Authors: Reyes-Martinez, Cristian, Nguyen, Quynh My, Kassan, Modar, Gonzalez, Alexis A.
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2019
Fag:
Pharmacology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6664006/
https://ncbi.nlm.nih.gov/pubmed/31396082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2019.00803
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