Therapeutic reduction of ataxin 2 extends lifespan and reduces pathology in TDP-43 mice

Amyotrophic lateral sclerosis (ALS) is a rapidly progressing neurodegenerative disease characterized by motor neuron loss, leading to paralysis and death 2–5 years following disease onset(1). Nearly all ALS patients contain aggregates of the RNA-binding protein TDP-43 in the brain and spinal cord(2)...

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Detalhes bibliográficos
Publicado no:Nature
Main Authors: Becker, Lindsay A., Huang, Brenda, Bieri, Gregor, Ma, Rosanna, Knowles, David A., Jafar-Nejad, Paymaan, Messing, James, Kim, Hong Joo, Soriano, Armand, Auburger, Georg, Pulst, Stefan M., Taylor, J. Paul, Rigo, Frank, Gitler, Aaron D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5642042/
https://ncbi.nlm.nih.gov/pubmed/28405022
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature22038
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