ALS-Associated Ataxin 2 PolyQ Expansions Enhance Stress-Induced Caspase 3 Activation and Increase TDP-43 Pathological Modifications

Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease caused by the loss of motor neurons. The degenerating motor neurons of ALS patients are characterized by the accumulation of cytoplasmic inclusions containing phosphorylated and truncated forms of the RNA-binding protein...

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Bibliographic Details
Main Authors: Hart, Michael P., Gitler, Aaron D.
Format: Artigo
Language:Inglês
Published: Society for Neuroscience 2012
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Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3418890/
https://ncbi.nlm.nih.gov/pubmed/22764223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0996-12.2012
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