Reduction of Matrix Metalloproteinase 9 (MMP-9) protects motor neurons from TDP-43-triggered death in rNLS8 mice

Therapeutic strategies are needed for the treatment of amyotrophic lateral sclerosis (ALS). One potential target is matrix metalloproteinase-9 (MMP-9), which is expressed only by fast motor neurons (MNs) that are selectively vulnerable to various ALS-relevant triggers. Previous studies have shown th...

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Enregistré dans:
Détails bibliographiques
Publié dans:Neurobiol Dis
Auteurs principaux: Spiller, Krista J., Khan, Tahiyana, Dominique, Myrna A., Restrepo, Clark R., Cotton-Samuel, Dejania, Levitan, Maya, Jafar-Nejad, Paymaan, Zhang, Bin, Soriano, Armand, Rigo, Frank, Trojanowski, John Q., Lee, Virginia M-Y.
Format: Artigo
Langue:Inglês
Publié: 2018
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7053168/
https://ncbi.nlm.nih.gov/pubmed/30458231
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2018.11.013
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