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Artificial Macrocycles as Potent p53–MDM2 Inhibitors
[Image: see text] Based on a combination of an Ugi four component reaction and a ring closing metathesis, a library of novel artificial macrocyclic inhibitors of the p53–MDM2 interaction was designed and synthesized. These macrocycles, alternatively to stapled peptides, target for the first time the...
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| Gepubliceerd in: | ACS Med Chem Lett |
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| Hoofdauteurs: | , , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
American Chemical
Society
2017
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| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5641952/ https://ncbi.nlm.nih.gov/pubmed/29057045 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.7b00219 |
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