Artificial Macrocycles as Potent p53–MDM2 Inhibitors

[Image: see text] Based on a combination of an Ugi four component reaction and a ring closing metathesis, a library of novel artificial macrocyclic inhibitors of the p53–MDM2 interaction was designed and synthesized. These macrocycles, alternatively to stapled peptides, target for the first time the...

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Опубликовано в: :ACS Med Chem Lett
Главные авторы: Estrada-Ortiz, Natalia, Neochoritis, Constantinos G., Twarda-Clapa, Aleksandra, Musielak, Bogdan, Holak, Tad A., Dömling, Alexander
Формат: Artigo
Язык:Inglês
Опубликовано: American Chemical Society 2017
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5641952/
https://ncbi.nlm.nih.gov/pubmed/29057045
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.7b00219
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