Point mutation of Ffar1 abrogates fatty acid-dependent insulin secretion, but protects against HFD-induced glucose intolerance

OBJECTIVE: The fatty acid receptor 1 (FFAR1/GPR40) mediates fatty acid-dependent augmentation of glucose-induced insulin secretion (GIIS) in pancreatic β-cells. Genetically engineered Ffar1-knockout/congenic mice univocally displayed impaired fatty acid-mediated insulin secretion, but in vivo experi...

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Bibliographic Details
Published in:Mol Metab
Main Authors: Sabrautzki, Sibylle, Kaiser, Gabriele, Przemeck, Gerhard K.H., Gerst, Felicia, Lorza-Gil, Estela, Panse, Madhura, Sartorius, Tina, Hoene, Miriam, Marschall, Susan, Häring, Hans-Ulrich, Hrabě de Angelis, Martin, Ullrich, Susanne
Format: Artigo
Language:Inglês
Published: Elsevier 2017
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Brief Communication
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5641630/
https://ncbi.nlm.nih.gov/pubmed/29031729
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2017.07.007
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