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FFA2-, but not FFA3-agonists inhibit GSIS of human pseudoislets: a comparative study with mouse islets and rat INS-1E cells

The expression of short chain fatty acid receptors FFA2 and FFA3 in pancreatic islets raised interest in using them as drug targets for treating hyperglycemia in humans. This study aims to examine the efficacy of synthetic FFA2- and FFA3-ligands to modulate glucose-stimulated insulin secretion (GSIS...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Lorza-Gil, Estela, Kaiser, Gabriele, Rexen Ulven, Elisabeth, König, Gabriele M., Gerst, Felicia, Oquendo, Morgana Barroso, Birkenfeld, Andreas L., Häring, Hans-Ulrich, Kostenis, Evi, Ulven, Trond, Ullrich, Susanne
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7536384/
https://ncbi.nlm.nih.gov/pubmed/33020504
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-73467-5
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