Palmitate and insulin counteract glucose-induced thioredoxin interacting protein (TXNIP) expression in insulin secreting cells via distinct mechanisms

Glucose and palmitate synergistically stimulate insulin secretion, but chronically elevated they induce apoptotic β-cell death. The glucotoxic effect has been attributed, at least partly, to the upregulation of the oxidative stress marker thioredoxin interacting protein (TXNIP). Palmitate downregula...

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Veröffentlicht in:PLoS One
Hauptverfasser: Panse, Madhura, Kluth, Oliver, Lorza-Gil, Estela, Kaiser, Gabriele, Mühlbauer, Eckhard, Schürmann, Annette, Häring, Hans-Ulrich, Ullrich, Susanne, Gerst, Felicia
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2018
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5973613/
https://ncbi.nlm.nih.gov/pubmed/29813102
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0198016
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